A DT-diaphorase responsive theranostic prodrug for diagnosis, drug release monitoring and therapy.
نویسندگان
چکیده
A DT-diaphorase-activatable theranostic prodrug, which contains camptothecin, a self-immolative linker and a trigger group, has been developed for the detection of DT-diaphorase, tracking of drug release and selectively killing cancer cells over-expressed with DT-diaphorase. This strategy may offer a new approach for the development of enzyme-catalyzed theranostic anticancer therapeutics.
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ورودعنوان ژورنال:
- Chemical communications
دوره 51 46 شماره
صفحات -
تاریخ انتشار 2015